BLOG ANDROLOGICA.ES

Dr.Cunill

La diferenciación sexual: ¿masculino o femenino?

By: | Tags: | Comments: 60 | enero 13th, 2018

-Lo que ocurre en el embrión:

La diferenciación sexual en el embrión humano, es en sí misma la diferenciación en sentido masculino, ya que el sexo por defecto es el femenino; esto quiere decir que para que se desarrolle el embrión masculino, debe desviarse ese camino natural que llevaría al embrión a diferenciarse en sentido femenino.
Esto se logra a partir del producto de un gen, el gen SRY, que se encuentra en el cromosoma Y, de los varones, el que entre sus acciones más importantes, estimula la persistencia de los cordones sexuales primarios, lo que es sinónimo de la transformación de la gónada indiferenciada en testículo, ya que de atrofiarse los mismos, serían reemplazados por los cordones sexuales secundarios, característicos del ovario.
Una vez que la gónada del embrión se ha diferenciado en testículo, en él podemos encontrar las células de Sértoli y las de Leydig, cada una con funciones importantes en este mecanismo de diferenciación en sentido masculino:
Las células de Sértoli elaboran hormona anti-mülleriana (HAM) que induce la involución del conducto de Müller (Muller 1832).Las células de Leydig sintetizan andrógenos (testosterona) que cumplen una doble función en este mecanismo: por un lado estimulan la persistencia y desarrollo de los conductos de Wolff (Caspar Wolff, 1820) y por otra parte masculinizan los genitales externos.
En el embrión femenino, en el ovario, no encontramos ninguno de estos dos tipos celulares, por lo tanto no habra ni HAM, por lo tanto no se atrofia el conducto de Müller y ante la falta de andrógenos, sí desaparece el de Wolff (por falta de testosterona) de esta manera, los genitales externos evolucionarán en sentido femenino.
Es sorprendente la cantidad de trastornos y patologías que hay, por estas complejas cascadas que existen para la generación de hormonas, como por ejemplo el síndrome de Morris o pseudohermafroditismo masculino, ya que es una enfermedad donde el individuo afectado tiene un genotipo y fenotipo (caracterísicas heredadas y apariencia externa) de diferentes sexos, vendría a ser como el caso de un transgénero congénito, en sentido figurado, por causas naturales, sin que intervenga, ningún agente externo.

-El síndrome de Morris:

Este síndrome se define como una anomalía física, en la que una persona cuenta con la genética de un sexo (masculino) y los genitales de otro (femenino). Esto también es conocido como (SIA): sindrome de insensibilidad a los andrógenos (testosterona), por ausencia de receptores.
La anomalía se debe a que los hombres son resistentes a las hormonas masculinas, es decir, los andrógenos (testosterona entre ellos). Lo cual provoca el desarrollo no sólo de los órganos genitales del otro sexo, sino que también el aspecto será el de una mujer y no darse cuenta nadie, de que hay una patología, hasta la adolescencia, en la que no aparecerá la menstruación.Por lo tanto la asignación sexual, será de mujer, desde el nacimiento.
Presentarán rasgos femeninos, órganos sexuales femeninos o similares, testosterona con niveles similares a los del hombre, pero debido a la patología los andrógenos no pueden actuar normalmente.
El síndrome de Morris( descrito 1953) es una enfermedad rara, (fué descrita como síndrome de feminización testicular), ya que afecta tan sólo a 1 de cada 40.000 bebés niños nacidos. Sin embargo, debido a solo se conocen algunos casos, es posible que la prevalencia sea aún mayor.Se considera que es la tercera causa de amenorrea en la pubertad.
En la forma severa, los genitales son femeninos pero a veces pueden presentar problemas como un tamaño más reducido de la vagina, y sin conexión a otro órgano, con hipoplasia de los labios de la misma.La mayoría poseen testículos, pero estos no descendieron y permanecen en el abdomen. Los cuales suelen extirparse, cuando se hace el dianóstico para evitar el desarrollo de cáncer en el futuro.
A las personas afectadas no les aparece (o lo hace de forma escasa) vello en las axilas o en el pubis. En la pubertad no hay menstruación, ya que genéticamente son hombres.Los individuos afectados son infértiles, ya que no se han desarrollado, ni los ovarios, ni el útero.
Causas del síndrome de Morris:
La enfermedad es de carácter hereditario, donde existe una mutación en un gen, llamado AR, que se encuentra en el cromosoma X, ya que los hombres solo tienen un cromosoma X, es más fácil que desarrollen la enfermedad, en tanto la mujer puede ser portadora de la mutación del gen, y transmitirla a un hijo . Lo que provoca el problema, es la ausencia de receptores, que son las proteínas AR (receptores de andrógenos), lo cual no permite actuar en conjunto con la testosterona para la formación o desarrollo masculino; lo que significa que la persona es resistente a la testosterona.
Para explicar el proceso de forma mucho más sencilla, debe tenerse en cuenta que las mujeres presentan los cromosomas XX, mientras que los hombres los XY. Su principal diferencia es que los hombres producen testosterona y esta hormona se encarga del desarrollo del individuo masculino. Cuando el cuerpo tiene ausencia de la misma, (en este caso la hay, generada por el propio embrión pero es como si no la hubiera, ya que al no haber receptores, se transformá en estrógeno), entonces el individuo se desarrolla como una mujer externamente a pesar que en el interior sigue siendo hombre, en sus genes.

Diagnóstico del síndrome de Morris:

El diagnóstico no suele hacerse en la etapa de la niñez del individuo, puesto que en ese momento aún no presenta síntomas que indiquen que padec e esta henfermedad. Es en la etapa de la pubertad cuando el problema es manifiesto, donde los médicos podrán realizar diferentes pruebas para diagnosticar a la persona:
Un estudio cromosómico puede constatar la existencia del cariotipo 46 XY, característico de las personas que presentan el síndrome.Debido a que la vagina suele ser ciega y de menor tamaño, con la ayuda de una ecografía ginecológico se podría observar la ausencia de útero y ovarios.
Las personas afectadas con el síndrome, reciben tres tratamientos: terapia de dilatación, gonadectomía y terapia psicológica que ayudará a que el paciente pueda sentirse a gusto con su cuerpo, como debe ser y evitar complejos absurdos.
En la pubertad, se desarrollan los caracteres sexuales femeninos, alcanzando una total apariencia de mujer, por la acción del estradiol,que se genera a partir de la testosterona, que es transformada por la acción de una enzima llamada aromatasa.
Comparte:

Comments

60 thoughts on “La diferenciación sexual: ¿masculino o femenino?

  1. http://www.funz.co

    I like the helpful information you supply in your articles.
    I will bookmark your weblog andd test again right here regularly.
    I’m rather certain I’ll be told many new stuff proper right here!
    Best of luck for the next!

    Responder

  2. http://www.ssdl.es

    Thanks forr one’s marvelous posting! I truly enjoyed reading it, you mmay be a great author.I will make sure to bookmark your blog and will come back very
    soon. I want tto encourage you to definitely continue your great job,
    have a nice afternoon!

    Responder

  3. dimagrire velocemente dieta

    Hey there! I know this is somewhat off-topic however I had
    to ask. Does operating a well-established blog like yours
    take a lot of work? I’m completely new to operating a blog but I do write
    in my journal on a daily basis. I’d like to start a blog so I will be able to share my
    own experience and views online. Please let me know if you have any recommendations or tips for brand new aspiring bloggers.

    Thankyou!

    Responder

  4. dieta per dimagrire 10 kg

    Thanks for your personal marvelous posting! I seriously enjoyed reading it, you are a great author.I will be sure to bookmark
    your blog and will eventually come back down the road.
    I want to encourage continue your great writing, have a nice morning!

    Responder

  5. implanty

    Hi! I just wanted to ask if you ever have any trouble with hackers?
    My last blog (wordpress) was hacked and I ended up losing many months of hard work due
    to no back up. Do you have any methods to prevent hackers?

    Responder

  6. http://www.sportsshop.uk.com

    Wonderful goods frfom you, man. I have remember your
    stuff prior to and you’re simply too wonderful.
    I really like what you’ve bought right here, certainly like what you’re sasying and
    the way inn which during which you assert
    it. You are making it enjoyable and you still care
    for to keep iit sensible. I can’t wait to read faar more from you.
    This iis actually a wonderful website.

    Responder

  7. Best Deals

    I was wondering if you ever thought of changing the layout of your website?
    Its very well written; I love what youve got to say.
    But maybe you could a little more in the way of content so
    people could connect with it better. Youve got an awful lot of
    text for only having 1 or two images. Maybe you could space it out better?

    Responder

  8. her latest blog

    Pretty section of content. I just stumbled upon your site and in accession capital to assert that I get actually enjoyed account your blog
    posts. Any way I will be subscribing to your augment and even I achievement
    you access consistently fast.

    Responder

  9. ballon de gym

    It is appropriate time to make a few plans for the long run and
    it is time to be happy. I’ve read this post and
    if I could I desire to recommend you some fascinating issues or suggestions.
    Maybe you could write subsequent articles regarding
    this article. I want to learn even more things about
    it!

    Responder

  10. blog bệnh

    You actually make it seem so easy with your presentation but I find this topic to be actually something
    which I think I would never understand. It seems too complicated and very broad
    for me. I am looking forward for your next post, I’ll try to get the hang of it!

    Responder

  11. realistic dildo

    I don’t even know how I stopped up here,
    but I assumed this post was once great. I don’t recognize who you might be but certainly you are going to a well-known blogger when you
    are not already. Cheers!

    Responder

  12. http://www.cgkz.de

    I think this is among the most vital info for me.
    And i’m glad reading your article. But wanna
    remark on some genral things, The web site style is wonderful, the articles is really
    great : D. Goood job, cheers

    Responder

  13. Tivat apartments

    This residential condominium is situated on landscaped residence that is at
    ground degree. This expression loosely describes any apartment on the to
    start with ground. It also involves a basement condominium or one in a higher increase.
    If it is a authentic backyard garden condominium, there will be
    no domestic, or condominium, above it. They are
    unfold out horizontally in an open up courtyard. You
    can come across these apartments worldwide.

    These kinds of an apartment will have a single or two bedrooms but you can obtain some
    that have three or much more bedrooms, especially if they
    are employed as a vacation condominium. The far more bedrooms there are the extra men and women they can accommodate when on holiday vacation and leasing the apartment.
    If it is an condominium that is rented out very long term it is frequently not furnished.
    If the condominium is rented out on a weekly or regular basis for holidays, it will be furnished.
    Backyard garden residences may possibly also have just one or two tales.
    The common space can consist of outside facilities like a swimming pool,
    tennis or basketball courts, a spa or clubhouse. The entrance to the condominium could be off the
    courtyard or the road.

    The owners of the back garden residences are liable for the outside place remaining retained up
    with the lawn mowed, any out of doors equipment cleaned, clean swimming pool without leaves and other debris, and so forth.
    Many proprietors will plant the place with perfectly cared for
    trees and floors. If it is an condominium sophisticated and you have a pet you need to
    have to find out if there is a unique place for the puppies.
    Make guaranteed that you clean up immediately after your canine the moment it has completed its
    company. Your backyard condominium may well have a compact yard or patio.
    If your backyard condominium has possibly of these two amenities, it would be a very good
    spot to have good friends and relatives more than for a barbeque.

    Just about every backyard garden apartment is a separate household unit
    but all of the tenants share any amenities, these kinds of as a swimming pool or exercising place and
    the main exterior grounds. The apartments have their very own controls
    for the warmth and air conditioning and toilet and kitchen area facilities.
    In some areas, it might be named a walk-up garden condominium due to
    the fact it has an out of doors staircase. With backyard garden apartment complexes that present premium solutions
    like a pounds and physical exercise area or sauna may well
    be billed an additional monthly price to help with the maintenance and have a key to permit them into these facilities.
    By owning a vital, it prevents all those that pick out not
    to shell out the added charge from using these top quality amenities.
    Some may even have a laundry place for the inhabitants.
    The rent for a backyard apartment would be a lot the identical as
    a normal apartment but it relies upon on the locale and features.

    Responder

  14. bryg.ru

    I love your blog.. very nice colors & theme. Did you
    design this website yourself or did you hire someone to do itt for you?
    Plz respond as I’m looking to create my own blog and woould like to find
    out where u got this from. many thanks

    Responder

  15. sign neon

    I used to bee suggeste this webb site by way oof my cousin.
    I’m no longer positive whether or not this submit iss written by way of him as no onee else know such certain approximately my difficulty.
    You’re incredible! Thanks!

    Responder

  16. crack adobe softwares

    After exploring a handful of the articles on your website,
    I honestly appreciate your technique of blogging.
    I saved it to my bookmark webpage list and will be checking
    back soon. Please check out my website as well and let me know what you think.

    Responder

  17. cheap tamsulosin

    Simply desire to say your article is as astonishing. The
    clarity in your publish is simply cool and that i can think you’re knowledgeable
    on this subject. Well along with your permission let me to grasp your feed to stay
    updated with impending post. Thank you one million and please continue the enjoyable work.

    Responder

  18. dogs and babies

    I’ve been surfing online more than three hours today, yet
    I never found any interesting article like yours. It’s pretty
    worth enough for me. Personally, if all webmasters and bloggers
    made good content as you did, the internet will be
    a lot more useful than ever before.

    Responder

  19. adorable baby

    My coder is trying to convince me to move to .net from PHP.
    I have always disliked the idea because of the costs. But
    he’s tryiong none the less. I’ve been using WordPress on a number of websites
    for about a year and am worried about switching
    to another platform. I have heard great things about
    blogengine.net. Is there a way I can transfer all my wordpress content into it?
    Any help would be greatly appreciated!

    Responder

  20. news

    Does your site have a contact page? I’m having a tough time locating it but, I’d like to shoot you an e-mail.
    I’ve got some creative ideas for your blog you might be interested in hearing.
    Either way, great site and I look forward to seeing it
    expand over time.

    Responder

  21. worst ceo

    Hi there! This article could not be written any better! Going through this article reminds
    me of my previous roommate! He always kept preaching about this.
    I’ll send this article to him. Fairly certain he’ll have a very good read.
    Many thanks for sharing!

    Responder

  22. http://minocyclinehere.gq

    Howdy just wanted to give you a quick heads up.
    The text in your content seem to be running off the screen in Safari.
    I’m not sure if this is a formatting issue or something to do with internet browser compatibility but I thought I’d post to let you know.

    The design look great though! Hope you get the issue fixed soon.
    Many thanks

    Responder

  23. worst website

    great publish, very informative. I’m wondering why the opposite experts of
    this sector do not realize this. You should continue your
    writing. I’m sure, you’ve a huge readers’ base already!

    Responder

  24. cash for cars

    You can certainly see your skills in the article you write.
    The sector hopes for more passionate writers
    like you who are not afraid to mention how they believe.
    At all times follow your heart.

    Responder

  25. buy loratadine

    Hey I know this is off topic but I was wondering
    if you knew of any widgets I could add to my blog that automatically tweet my newest
    twitter updates. I’ve been looking for a plug-in like this for quite some time and
    was hoping maybe you would have some experience with something like this.
    Please let me know if you run into anything. I
    truly enjoy reading your blog and I look forward to your new updates.

    Responder

  26. Http://Www.Watermelon.Nu/Cgi-Bin/Bbs/Aska.Cgi/?Guid=On

    Who’s using Fb Messenger? Instant messages are often logged in a local message historical past, making it just like the
    persistent nature of emails. A pre-ICO crowdsale is presently energetic,
    throughout which traders can purchase E-Chats ECHT tokens with
    a 30% low cost. At current, e-Chat is in its first stage of
    ICO that will end on Dec 15. Anybody who wants to try the app is welcome to obtain it from Google Play and App Store To help the venture, customers could buy ECHT tokens at $zero.seventy five.
    The time to invest beneath the most favorable conditions is proscribed — token price will enhance during the next phases of ICO.

    These chatbots are convenient for patrons who already know your model and what they want.
    In addition to the malicious code menace, the use of prompt messaging at work also
    creates a threat of non-compliance to laws and regulations governing use of digital communications in companies.
    This may not matter to you, but if it does, it is best to make appointments
    along with your contacts for specific times to fulfill online.
    You will should be linked to Tor before you can configure your Jabber account.

    Moderately than other utility e-Chat app is too
    much secured about your messages, recordsdata or cash transactions.
    Conversations feel real and alive making clients really feel closer to you and
    your group. We consider that the existing centralized architecture used
    as the mannequin for all known immediate messaging
    apps threatens the liberty and safety of recent online communication. Create a Jabber account
    utilizing Tor Browser. If accomplished correctly, Fb Chatbots present monumental potential (a connection to 900 million folks on FB Messenger ) to drive gross sales and improve
    the client relationship.

    If you add a Jabber contact you may’t instantly tell in the event that they’re online or not.
    The market already has numerous prompt messengers, but e-Chat has a range of … Proceed studying The First Decentralized Multi Process e-Chat Messenger Pre-ICO Begins!

    ChatWoot Customer support bots for Messenger. At the similar time,
    we additionally began testing a way so that you can share these pictures and movies — as they
    occur — by adding to your Messenger Day, the place
    many of your pals can view and reply to them.

    Very happy that I installed this app and I don’t hesitate to suggest it or the crew behind it.
    Excellent customer service and assist if you want it.
    If you happen to sell merchandise like attire with multiple options (dimension, colour, model,
    and so forth.), it may be simpler to direct your clients
    to browse your web site to be able to provide a better
    expertise. The presence of e-Chat in the digital arena has been observed by such authoritative publishers as The Huffington Publish, The Next Internet and Forbes which highlighted the decentralized construction and excessive level of knowledge encryption as
    the most significant advantages of messenger.

    These sites gives you a place to begin if you happen to’re
    able to build your first Fb Messenger chatbot. E-chat will utilize this information for making a protected smart
    contract which is the escrow between the vendor and the
    buyer on the application. You will want an existing Facebook Web
    page and administrator rights to handle it.
    Use ManyChat to create your bot in 2 minutes with out coding.

    E-Chat provides the identical sort of service with a twist.
    You can not send a textual content from Skype to Telegram
    and arrange a video streaming from Fb messenger to Viber.

    If we take other instant messengers into consideration, they provide even much less space for any additional improvement, basically,
    none. E-Chat is a social network of a new technology that means that you
    can be in touch with folks in addition to commerce in cryptocurrencies.
    Within the latter half of the 1980s and into the early Nineteen Nineties,
    the Quantum Link on-line service for Commodore 64 computer systems provided person-to-user messages between concurrently
    linked customers, which they called “On-Line Messages” (or OLM for short), and later “FlashMail.” (Quantum Link later turned America
    Online and made AOL Instantaneous Messenger (PURPOSE, mentioned later).

    In the intervening time, e-Chat is just not only an incredible idea, however already a working messenger that features in beta-version. You can also provide your clients an opportunity
    to use Messenger to deal with order and delivery confirmations.

    The most effective thing about chatbots is that they
    provide you an automatic, cost-effective option to talk together with your clients in a manner
    that’s extra direct and private than ever before. It’s a
    win-win: your prospects get fast access to help and wait occasions keep low by hunting down unnecessary calls.

    E-Chat will likely be created to beat from that privacy concern and also
    to achieve cash and all this is accomplished instantly.
    Listed below are a few Jabber servers you can create new accounts on utilizing
    Tor Browser, chosen at random from the general public lists: ChatMe (primarily based in Italy), CodeRollers (primarily based in Romania), Darkness XMPP
    (based mostly in Russia), KodeRoot (based within the U.S.),
    (based in Austria), Sizzling-Chilli (based mostly in Germany), (primarily based in Japan),
    and the record goes on and on. http://Www.watermelon.nu/cgi-bin/bbs/aska.cgi/?guid=on

    Responder

Leave a Reply

EnglishFrenchSpanish
Info. ContactoCuestionarioLlamar
A %d blogueros les gusta esto: